I'm going to answer my own question in hopes that it helps someone else having the same problem. I felt like I thoroughly uninstalled all remnants of Dexpot. I was still getting disappearing programs and text would briefly flash in the corner of the screen that was the name of several of the desktop...

I've been trying the latest Dexpot on my Windows 10 machine that has 3 monitors. Two are standard screens and one is a Cintiq 13HD. All was great for a few days. Then programs began just disappearing. I'd click to save a file and the whole program would disappear just leaving the "save to"...